A Randomized Controlled Trial Comparing Methotrexate Iontophoresis and Oral Methotrexate for the Treatment of Hyperkeratotic Palmoplantar Eczema.

Cureus · 2025 · PMC12143960 · PMID 40486413

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

highly significantP < 0.05actually significant

Statistical analysis revealed that the pre-and post-treatment changes in HECSI scores were highly significant in both treatment groups ( P < 0.05), confirming the clinical effectiveness of both therapeutic approaches.

also in 132,142 other papers

did not reach statistical significanceno p-value reported

Group B exhibited a marginally higher mean improvement in palm lesions compared to Group A; however, this difference did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.