Barely Significant
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Benchmarking AlphaMissense pathogenicity predictions against <i>APP, PSEN1,</i> and <i>PSEN2</i> variants of unknown significance.

Biochem Biophys Rep · 2025 · PMC12145806 · PMID 40486492

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a clear trendno p-value reported
The findings from this study support this conclusion as Aβ40 levels were negatively correlated with predicted pathogenicity than Aβ42 that did not have a clear trend.

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