Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.

Using the RNA‐seq samples, four out of the five genes downregulated in 5‐HTT −/− rats by RNA‐seq were significantly downregulated when assessed by RT‐qPCR as well ( Slc6a4 ( t (1,4.39) = 5.20; p < 0.05); Car4 ( t (1,4.07) = 3.90; p < 0.05); Calb2 ( t (1,7) = 3.93; p < 0.05); Kcnh5 ( t (1,7) = 3.17; p < 0.05)); and Htr2a showed a trend ( t (1,7) = 2.18; p < 0.1).

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