Systemic inflammatory indices and the risk of depression in individuals with sleep difficulties: A cohort study based on NHANES 2005-2020.

Compr Psychoneuroendocrinol · 2025 · PMC12148667 · PMID 40496709

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a significant trendno p-value reported

Compared with those in the lowest quartile, participants in the highest NPR quartile had 49 % greater odds of developing depression (OR: 1.49, 95 % CI = 1.04–2.13, p = 0.034), with a significant trend across quartiles (p-trend<0.001).

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highly significantno p-value reported

Our subgroup analysis revealed that in males, the association between the SIRI and the risk of developing depression was highly significant (OR: 3.26, 95 % CI = 1.46–7.28), much greater than that in females (OR: 1.44, 95 % CI = 0.80–2.59), as was the association between the NPR and the risk of developing depression.

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