Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China.

The difference between monotherapy and polypharmacy was highly significant ( p = 0.0011 [t = 3.276; df = 748]).

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Even though male patients generally showed higher weight gains than female patients, the respective differences did not reach statistical significance.

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