Compared with low neuroticism, high neuroticism was associated with an increased risk of transitions from a healthy state to a first neuroticism-related disease (1.09 [1.05–1.13], P <0.001) and subsequent transitions to multimorbidity (1.08 [1.02–1.14], P = 0.005), but were associated with a decreased risk of transitions from the first disease to death (0.53 [0.37–0.76], P <0.001) and with a significant trend toward a decreased risk of transitions from multimorbidity to death (0.90 [0.84–0.97], P for trend = 0.006) [Figure 4 ].
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