Overall Survival and Prognostic Factors in De Novo Metastatic Human Epidermal Growth Factor Receptor (HER)-2-Positive Breast Cancer: A National Cancer Database Analysis.

Cancers (Basel) · 2025 · PMC12153553 · PMID 40507304

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

a clear trendno p-value reported

Charlson–Deyo comorbidity score groups of one (HR 1.23, 95% CI 1.07–1.41), two (HR 2.36, 95% CI 1.93–2.88) and three or more (HR 3.72, 95% CI 3.11–4.45) were associated with worse OS rates compared to the score 0 group, demonstrating a clear trend of decreasing survival as the comorbidity burden increased.

also in 19,460 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.