RNA Sequencing Identifies WT1 Overexpression as a Predictor of Poor Outcomes in Acute Myeloid Leukemia.

Cancers (Basel) · 2025 · PMC12153777 · PMID 40507300

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0890

boldest claim

The sentences

highly significantp < 0.001actually significant

The statistical comparison indicates a highly significant difference in expression levels between diagnostic and relapse cases ( p < 0.001), suggesting that WT1 expression dynamically reflects disease burden and treatment response.

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borderline significantp = 0.05actually significant

A borderline significant difference was found in blast percentage ( p = 0.05), with more patients in the WT1 high group having blast counts ≥80%.

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approached significancep = 0.089so close (0.05 < p ≤ 0.1)

Gender remained significant for EFS (HR: 1.62, p = 0.028), with females at higher risk, and approached significance for OS (HR: 1.52, p = 0.089).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.