The Glu component of the Gln-Glu cycle, known to be essential for respiratory rhythm generation ( Cook-Snyder et al., 2019 ), decreased after morphine in both groups of mice; however, the decrease in the wild-type did not reach statistical significance.
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<sup>1</sup>H MRS-based metabolite changes at ventral respiratory control centers of the medulla oblongata following administration of morphine in wild-type and GIRK2 mutant mice.
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