Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2.

Front Cell Dev Biol · 2025 · PMC12158927 · PMID 40510743

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Interestingly, the presence of amiloride in combination with LEFTY2 pre-treatment showed a trend towards an even greater reduction in [Ca 2+ ] i , though this combined effect did not achieve statistical significance, as indicated in Figures 2a, b, f . 3.3 LEFTY2 attenuates trypsin-induced upregulation of L-type calcium channels The previous results showed that decrease of calcium does not occur by blocking ENaC.

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