On the multiplicative scale, nominally significant interactions between endometriosis PRS and comorbidity diagnosis were noted: there was a significant negative interactive effect for asthma ( p = 0.016) and irritable bowel syndrome ( p = 0.018) in the UKB and for heavy menstrual bleeding in the EstBB ( p = 0.02) ( Table S9 ).
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Interaction between genetic risk and comorbid conditions in endometriosis.
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