ZEB2 upregulation modulates the polarization of TAMs toward the immunosuppressive state in EGFR-TKI-resistant NSCLC.

Figure 5E shows that although higher concentrations of U0126 (10 μM) induced a trend toward ZEB2 downregulation in both PC9-GR and HCC827-GR cell lines, this trend did not reach statistical significance.

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Moreover, at a lower concentration of U0126 (5 μM), a nonsignificant trend toward ZEB2 upregulation was noticed in the PC9-GR cell line.

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