Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer.

KRAS ‐mutated MSS samples showed a trend toward having lower activation of immune response pathways, that is, having significantly lower activities in JAK–STAT and NFkB pathways relative to the RAS_RAF_GNAS_wt MSS samples in the second patient cluster (Fig. 4A ).

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Patient ACCC_CRC_15, the only MSI sample in this cluster, also showed an overall trend of under‐activation in the majority of estimated pathway and TF activities, whereas the EGFR signaling cascade and MYC TF were found significantly over‐activated in this POLE ‐mutant tumor.

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