Notably, only the STROKESTOP trial demonstrated a statistically significant reduction in its primary outcome—a composite of ischemic or hemorrhagic stroke, systemic embolism, hospitalization for bleeding, and all-cause mortality (hazard ratio 0.96; 95% CI: 0.92–1.00)—while the reduction in ischemic strokes did not reach statistical significance (hazard ratio 0.92; 95% CI: 0.83–1.01).
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Clinical outcomes of atrial fibrillation screening: a meta-analysis of randomized controlled trials.
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Discussion This meta-analysis on the clinical outcomes of systematic electrocardiogram-based AF screening in individuals without known AF has three key findings: 1) AF screening is associated with a marginally statistically significant 7% relative reduction in the incidence of stroke and systemic embolism, 2) there is no signal of an increase harm in terms of major bleeding events, and 3) screening has no effect on all-cause mortality.