Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer.

Despite the impact on tumor volumes in groups treated with STING inhibition and CD4 + T cell-depletion, these groups did not reach statistical significance at the end of the experimental period as compared to the triple treatment group, an event most likely related to the high number of cured mice observed in these groups, which limits the statistical significance.

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