Barely Significant
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Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression.

EMBO Mol Med · 2025 · PMC12162873 · PMID 40263624

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may be significantno p-value reported
Further development may be significant for BML-260, which does not appear to have undergone any additional structural optimization since the initial publication by Cutshall et al (Cutshall et al, 2005 ).

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Western blotting indicated that DUSP22 knockdown increased fast myosin (MYH2) mean expression, although it did not reach statistical significance (Fig. 3I,J ).

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