Therapeutic potential of BOLD-100, a GRP78 inhibitor, enhanced by ATR inhibition in pancreatic ductal adenocarcinoma.

Cell Commun Signal · 2025 · PMC12164152 · PMID 40514666

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0.1589

closest p · 3.2× alpha

0.1589

boldest claim

The sentences

did not reach statistical significancep = 0.1589not close (p > 0.1)

BOLD-100 treatment induced ER stress and exhibited antitumor effects, as indicated by increased CHOP and a trend toward GRP78 downregulation in vivo, although the latter did not reach statistical significance ( p = 0.1589) (Fig. 6 B).

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