Smoking habit and long-term colorectal cancer incidence by exome-wide mutational and neoantigen loads: evidence based on the prospective cohort incident-tumour biobank method.

38 Using the likelihood ratio test (1 df), we examined a heterogeneity trend across tumour subtypes in a statistical trend of the association across smoking exposure levels. 39 The multivariable Cox regression model included the covariates described in table 2 .

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In an analysis stratified by tumour MSI status, we observed a stronger association of cumulative pack-years smoked with the incidence of tumours containing higher levels of e-TMB or neoantigen loads in the stratum of MSI-high tumours ( table 3 ), though the differential associations did not reach statistical significance.

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