ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function.

Knockdown of ADRB2 in Jurkat T cells slightly reduced the expression of PD-1 and NKG2A, both of which are immune checkpoints, although this did not reach statistical significance ( figure 3A and B ; online supplemental figure 2E-F ).

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