Prevention of Atrial Fibrillation After Cardiac Surgery: A Review of Literature and Comparison of Different Treatment Modalities.

109 Anglade et al demonstrated that the preoperative use of thiazolidinedione, which has some anti-inflammatory properties in diabetic patients undergoing cardiac surgery, was associated with a 20% reduction in postoperative AF, but it did not reach statistical significance due to the study being underpowered. 110 A large prospective observational study of 4657 patients undergoing cardiac surgery demonstrated that postoperative use of angiotensin-converting enzyme inhibitor (ACEI) reduced the incidence of postoperative AF after cardiac surgery by 38%. 111 Negative studies about the preventive effect of ACEIs and angiotensin receptor blockers (ARB) on postoperative AF have also been published.

also in 111,027 other papers