RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression.

J Clin Invest · 2025 · PMC12165809 · PMID 40519166

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 2.2 × 10 –16actually significant

A Fisher’s exact test confirmed that this difference is highly significant ( P < 2.2 × 10 –16 ), with an odds ratio of 2.76.

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showed a trendno p-value reported

From PCa patient database ( 30 ), patients with TRIM28 -high expression experienced significantly worse disease-free survival ( Figure 1E and Supplemental Figure 1A ; supplemental material available online with this article; https://doi.org/10.1172/JCI185119DS1 ) and showed a trend of worse overall survival ( Supplemental Figure 1B ).

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