Early cortical alterations and neuropsychological mechanisms in amyotrophic lateral sclerosis.

Neuroimage Clin · 2025 · PMC12166458 · PMID 40449058

Europe PMC DOI

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0.2320

closest p · 4.6× alpha

0.2320

boldest claim

The sentences

did not reach statistical significancep = 0.232not close (p > 0.1)

For early-stage detection (HC vs ALS 1), ALFF features exhibited perfect discrimination (AUC = 1.000, 95 %CI: 1.000–1.000), but the high performance did not reach statistical significance ( p = 0.232).

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a decreasing trendno p-value reported

Notably, we found increased CT in the left cingulate gyrus and frontal pole in ALS 1 patients, followed by a decreasing trend in ALS 2.

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