Circulating exosome-derived miR-191-5p is a novel therapeutic biomarker for radiotherapy in esophageal squamous cell carcinoma patients.

In patients who underwent chemoradiotherapy (CRT) followed by esophagectomy (excluding those who received CRT alone or salvage endoscopic submucosal dissection), those with high levels of exosomal miR-191-5p appeared to exhibit greater resistance to CRT compared to those with low levels of exosomal miR-191-5p, although this difference did not reach statistical significance (25.9% vs 13.8%, P = 0.3224).

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