Moreover PMA stimulated neutrophils from DADA2, showed a trend toward an increased “vital” NETosis, although not significant, again with no effect after ADE stimulation (Fig. 1 B).
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NET Proteomic Profiling Reveals New Pathways Potentially Implicated in Dendritic Cell-Mediated Inflammation in DADA2 Patients.
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One pathway enriched in cluster #296 and highly significant (FDR = 2,7E-14), including 27 proteins was “Myeloid cell activation involved in immune response”.