A large-scale ENIGMA multisite replication study of brain age in depression.

Neuroimage Rep · 2022 · PMC12172781 · PMID 40567563

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

did not reach statistical significancep = 0.055so close (0.05 < p ≤ 0.1)

A significant positive association between brain-PAD and BDI was found across diagnostic groups (N = 756, b = 0.04 years per symptom [SE = 0.02]; r = 0.08 [SE = 0.04], 95% CI: 0.00–0.15, p = 0.02), but this did not reach statistical significance within the patient group (N = 350, b = 0.07 years per symptom [SE = 0.04]; r = 0.09 [SE = 0.05], 95% CI: −0.01-0.20, p = 0.055).

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