Discovery of Proteoforms Associated With Alzheimer's Disease Through Quantitative Top-Down Proteomics.

By Fisher's exact test, this enrichment is highly significant ( p -value = 1 × 10 −14 ) in comparison to the global data in which oxidation represents <5% of observed modifications ( Fig. 2 D ).

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Out of the 55 VGF fragments quantified in our study, 27 were nominally significant in the association with cognitive decline while seven remained significant after adjustment of the p -values for multiplicity of hypothesis testing ( Fig. 7 ).

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