Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.

Although the conditional main effects of PGS did not reach statistical significance ( p s = 0.23–0.58), all coefficients of the conditional main effects were positive (ORs ranged from 1.06 to 1.17), with higher PGS associated with more HDDs.

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As reported in a prior analysis of the two studies combined (Kranzler, Hartwell, et al., 2021 ), there was a highly significant effect of topiramate treatment on HDDs.

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