The characteristics of HER2-positive microinvasive breast cancer and the necessity of systemic adjuvant therapy in these patients: a multicenter real-world study.

Both OS and distant metastasis-free survival tended to be shorter in patients with MIBC than in patients with DCIS, but the difference did not reach statistical significance. 24 Regarding the risk factors associated with relapse, a study including 1299 patients with MIBC reported that patients younger than 40 had poorer local-regional-free survival. 25 ER-negative invasive disease and the presence of lymphovascular invasion have also been identified as potential predictors of lymph node metastasis in MIBC patients. 26 , 27 However, the prognostic value of HER2 in MIBC is still controversial.

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