The Role of Iron Homeostasis Imbalance in T2DM-Associated Cognitive Dysfunction: A Prospective Cohort Study Utilizing Quantitative Susceptibility Mapping.

In this supplementary model, the estimated coefficient for the reverse path was −0.093 (SE = 0.054, Z = −1.707, p = 0.088), which did not reach statistical significance.

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This finding indicates that although there is a slight trend toward a reverse influence, its effect is relatively weak compared to the significant impact of metabolic dysregulation on brain iron deposition and, consequently, on cognitive function (Table S5 ). 3.5.4.

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