Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis.

Nat Med · 2025 · PMC12176629 · PMID 40301560

Europe PMC DOI

hedged sentence

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

showed a trendP = 0.066so close (0.05 < p ≤ 0.1)

Patients who progressed from PET imaging onwards showed a trend toward more rBRLs ( P = 0.066; Extended Data Fig. 8h,i ).

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