Evaluating the link between insulin resistance and cognitive impairment using estimated glucose disposal rate in a non-diabetic aging population: results from the CHARLS.

In contrast, the triglyceride glucose index (TyG) demonstrated a near-significant linear association with cognitive impairment risk (HR = 0.85, 95% CI: 0.72–1.00, P = 0.050), with participants in the highest TyG quartile showing robust protection against cognitive impairment (HR = 0.83, 95%CI: 0.73–0.95, P = 0.010) ( Supplementary Table 4 ).

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For the atherogenic index of plasma (AIP), linear regression analysis revealed a non-significant trend (HR = 0.90, 95%CI: 0.78–1.05, P = 0.170), although participants in the highest AIP quartile approached marginal significance (HR = 0.89, 95%CI = 0.78–1.02, P = 0.100) ( Supplementary Table 3 ).

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