An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant.

At 5 days post-infection, all LNP-mRNA-RBD vaccinations led to reductions in virus titres in the lungs relative to LNP-mRNA-OVA-immunisation (mean reductions in viral titres of 1.8–2.6 log 10 PFU g −1 ), although the difference in virus titres between LNP-mRNA-OVA-immunised mice and mice immunised with the ancestral-type vaccine twice did not reach statistical significance.

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