The difference of variation types between late-onset multiple acyl-CoA dehydrogenase deficiency patients carrying biallelic and single heterozygous variations in ETFDH: a systematic review and meta-analysis.

Orphanet J Rare Dis · 2025 · PMC12178022 · PMID 40533849

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0.0840

closest p · 1.7× alpha

0.0840

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did not reach statistical significanceP = 0.084so close (0.05 < p ≤ 0.1)

Subgroup analyses revealed that the relative frequency was 76% (95% CI [70%-82%], I 2 = 34.84%; P–H = 0.033) in the biallelic group, which was higher than that in the heterozygous group (65%, 95% CI [51%-76%], I 2 = 0.00%; P–H = 0.714), although the difference did not reach statistical significance ( P = 0.084) (Fig. 3 ).

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