While we did not observe increased activity in the 3Rtau-tg mice, the 4Rtau-tg mice showed a trend toward increase in activity beginning at 3-months of age. 3R/4Rtau-tg mice had significantly greater spontaneous activity compared to 3Rtau-tg or non-tg mice beginning at 3-months of age and continuing through 9-months of age.
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Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology.
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