The Diagnosis of Sepsis-Associated Encephalopathy Using Biomarkers: Are We There Yet?

higher serum levels of matrix metalloproteinase-8 (MMP8) and calcium-binding protein A8 (S100A8) in critically ill septic patients with SAE compared to non-SAE patients, while the increase of other biomarkers studied (interleukin-6 [IL-6] and colony-stimulating factor 3 [CSF3]) in patients with SAE did not reach statistical significance. 10 All four biomarkers studied (S100A8, MMP8, CSF3, and IL-6) were significantly linked with the GCS scores of septic patients. 10 The S100A8 and MMP8 levels were helpful for the diagnosis of SAE, with S100A8 having a better prediction value than MMP8 (area under the receiver operating characteristic [AUC ROC] curve of 0.962 and 0.791, respectively).

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