The olfactory epithelium: a critical gateway for pathological tau propagation and a target for mitigating tauopathy in the central nervous system.

Although the difference did not reach statistical significance—likely due to variability in transduction efficiency—the pattern was consistent: all control mice displayed similar baseline levels of pathology, whereas all AAV-treated mice exhibited more advanced tau pathology, with severity likely varying in relation to the efficacy of AAV delivery (Fig. 9 d, e).

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