Implantation failure can only be recognized when there is a significant trend of undetectable tumor growth for at least 6 months or the observed mass is only proliferated by non-epithelial cells. 27 , 28 Moreover, PDX samples and data should be stored together with the patient’s clinical information to generate PDX libraries. 12 Interfering factors in the success rate of PDX modeling Successful construction of PDX models undoubtedly presents innovative opportunities for oncology research.
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Patient-derived xenograft models: Current status, challenges, and innovations in cancer research.
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