Barely Significant
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Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.

Geroscience · 2025 · PMC12181599 · PMID 40220152

Europe PMCDOI
2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0500
boldest claim

The sentences

a nonsignificant trendp = 0.05actually significant
In the posterior cingulate, regional CBF had a direct effect on global/memory impairment independent of volume reduction ( p = 0.02), and volume reduction showed a nonsignificant trend ( p = 0.05) towards an effect on global/memory impairment independent of regional CBF (Fig. 2 g).

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did not reach statistical significanceno p-value reported
However, indirect mediation effects in these regions did not reach statistical significance, preventing a definitive conclusion from being drawn regarding independent versus mediating effects of CBF and white matter integrity on attention/executive impairment.

also in 111,027 other papers

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