Pharmacological targeting of CBX7 alters the epigenetic landscape and induces differentiation of leukemic cells.

In addition, pretreatment with CBX7 inhibitors showed a trend toward reduced infiltration of hCD45 + AML cells in the spleen ( Figure 6 D,F) and reduced engraftment of hCD45 + AML cells in the BM ( Figure 6 E,G).

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