Single-cell profiling of peripheral blood mononuclear cells from patients treated with oncolytic adenovirus TILT-123 reveals baseline immune status as a predictor of therapy outcomes.

Correlation analysis revealed significant positive association between overall survival and percentage of predicted antiviral T cells ( p = 0.0362) as well as combined antiviral and antitumor T cells ( p = 0.0493), while antitumor TCRs showed a positive trend ( p = 0.1455) (Fig. 5I ).

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Comparison between response groups showed that most cell types had no statistical significance, although cytotoxic CD56 dim NK cells and Effector CD8 T cells demonstrated a trend toward higher levels in Responders, while Naïve and Central Memory CD4 T cells showed a trend toward higher levels in Non-Responders.

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