Mean ACOD1 concentration was higher in patients with EOCC compared to patients >50 years of age, with higher ACOD1 levels in both CC tissue and normal colon tissue; however, this did not reach statistical significance ( Figure 1D ). 3.3 Itaconate levels in normal colon tissue of young CC patients are higher than those seen in patients >50 years of age Figure 1E is showing itaconate concentrations in paired patient samples (CC/normal colon tissue and plasma).
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Itaconate and obesity-related hormones promote tumor progression - new insights on metabolic dysfunction in early-onset colon cancer.
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