The effect of chrysin on ischemia-reperfusion injury in the rat epigastric artery skin island flap.

Although improvements were observed in flap survival rate, oxidative stress index (OSI), and vascular proliferation at 10 mg/kg/day and 50 mg/kg/day doses, as well as in total oxidant status (TOS), tumor necrosis factor-alpha (TNF-α), active inflammation, chronic inflammation and ulceration across all treatment doses, these changes did not reach statistical significance.

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