Thyroid hormone enhances estrogen-mediated proliferation and cell cycle regulatory pathways in steroid receptor-positive breast Cancer.

Hyperthyroid women also treated with peri- and/or post-menopausal unopposed estrogen therapy <5 years in duration showed a highly significant and remarkable 62% increased risk of invasive BC (HR1.62, 95% CI 1.01–2.58) [ 20 ].

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In women with hyperthyroidism (treated or untreated), an increased risk of BC development was detectable but did not reach statistical significance.

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