Serendipitous and Systematic Chemoproteomic Discovery of MBLAC2, HINT1, and NME1-4 Inhibitors from Histone Deacetylase-Targeting Pharmacophores.

To test this hypothesis, we measured clathrin-mediated endocytosis of fluorescently labeled transferrin (TF) in the presence and absence of MBLAC2 inhibitors. While MBLAC2 inhibitors showed a trend toward reducing TF uptake, the results were not statistically significant ( Figure S6c ).

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