Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties.

Furthermore, compound 17 showed a tendency to attenuate MK-801-induced PPI deficits at a prestimulus of 84 and 90 dB, however, the effect did not reach statistical significance (F­(3,28) = 0.31, p = 0.82, Figure B and F (3,28) = 0.44, p = 0.72, Figure C).

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