Systematic mediation and interaction analyses of kidney function genetic loci in a general population study.

PLoS One · 2025 · PMC12186986 · PMID 40554574

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hedged sentence

0.0300

closest p · 0.6× alpha

0.0300

boldest claim

The sentences

nominally significantP = 0.03actually significant

Results did not support the presence of interaction with these two conditions at any locus after multiple testing control, despite nominally significant P -values observed for SNP interaction with hyperthyroidism at SHROOM3 ( P = 0.03) and with hypothyroidism at PIP5K1B ( P = 0.03) and GAB2 ( P = 0.04; S7 Table in S2 File ).

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