Exome sequencing and prenatal skeletal abnormalities: comprehensive review and meta-analysis and way forward.

Front Genet · 2025 · PMC12188644 · PMID 40567897

Europe PMC DOI

hedged sentence

0.6600

closest p · 13.2× alpha

0.6600

boldest claim

The sentences

did not reach statistical significancep = 0.66not close (p > 0.1)

When comparing fetuses with short bones less than –2SD to those with short bones below –4SD, the latter were more likely to be detected genetic abnormality with ES (22.2% for –2SD versus 50.0% for –4SD), but this difference did not reach statistical significance (p = 0.66).

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