Vagus Nerve Stimulation Regulates the Th17/Treg Balance and Alleviates Lung Injury in Acute Respiratory Distress Syndrome by Upregulating α7nAChR.

Biomedicines · 2025 · PMC12189159 · PMID 40564012

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Pathological assessment with H&E staining showed that the GTS-21 (α7nAChR agonist) preconditioned group exhibited significantly reduced lung histopathological injury and lower lung injury scores compared with the LPS + VNS group, whereas the MLA (α7nAChR antagonist) preconditioned group showed a trend toward increased injury and higher lung injury scores ( Figure 6 A,B).

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