Although not statistically significant, CM from PNF cells showed a trend toward increased levels of secretions compared to normal Schwann cells, including betacellulin (BTC), G-CSF (CSF-3), GRO alpha (CXCL1), IL-1 alpha, IL-1 beta, IL-3, IL-5, IL-6, IL-7R alpha, IL-9, IL-13, IL-27, IL-31, IL-33, MCP-1 (CCL2), MIP-1 beta (CCL4), RANTES (CCL5), and TNF alpha ( Figure 4 B). mRNA expression levels of key cytokines and chemokines were used to confirm the observations made on the multiplex assay.
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The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model.
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