DNA Damage Repair Pathway Alterations and Immune Landscape Differences in Pediatric/Adolescent, Young Adult (AYA) and Adult Sarcomas.

ATRX (1.6-fold, p < 0.0001) and BRCA2 (1.3-fold, p < 0.05) were associated with significantly higher GSS compared to respective WT subgroups, and FANCE (1.3-fold, p = 0.19), ERCC2 (1.2-fold, p = 0.15), PALB2 (1.2-fold, p = 0.32), and MSH2 (1.2-fold, p = 0.33) mutations showed a trend toward higher GSS, while a trend for lower GSS was observed for MRE11 (0.64-fold, p = 0.24) and CHEK2 (0.83-fold, p = 0.14) ( Figure 3 C). 3.4.

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